Retatrutide titration schedule
Build your retatrutide dose up step by step. Enter vial size and water, pick a titration protocol — and the tool shows exactly how many units to draw on the insulin syringe each week.
Inputs
Amount of retatrutide powder in the vial.
Volume you reconstitute with.
Pick your syringe size — this sets the scale of the syringe below.
Pick a common schedule or set your own values below.
Your titration schedule
| Week | Dose/week | Units |
|---|---|---|
| Week 1–4 | 2 mg | 20.0 U |
| Week 5–8 | 4 mg | 40.0 U |
| Week 9–12 | 6 mg | 60.0 U |
| From week 13Maintenance | 8 mg | 80.0 U |
U-100 insulin syringe · 100 units (1 ml = 100 units)
Tap a row to see the syringe for that week.
How is this calculated?
Concentration = vial (mg) ÷ water (ml)
Volume per dose = weekly dose (mg) ÷ concentration (mg/ml)
Units = volume (ml) × 100 — on a U-100 syringe, 1 ml = 100 units
The schedule raises the dose stepwise by the set increment, every set number of weeks, until the target dose is reached. After that the dose stays the same (maintenance).
For laboratory research use only. Not for human or veterinary use. This tool is a calculation aid, not medical advice. Always reconstitute with sterile bacteriostatic water and store per protocol.
What is a retatrutide titration schedule?
Retatrutide is a GLP-1/GIP/glucagon triple agonist that, in research, is titrated up gradually rather than started at the full dose. A titration schedule begins with a low starting dose and increases it every few weeks until the target dose is reached. This gradual build-up is used in clinical research to improve tolerability. This tool turns your vial size, water and chosen protocol into a concrete week-by-week schedule.
Converting retatrutide dosage to units
Dosage is usually expressed in milligrams (mg) per week, but on the insulin syringe you draw units (U). How many units one dose is depends entirely on your reconstitution: how many mg of powder are in the vial and how many ml of bacteriostatic water you dissolve it in. The less water, the higher the concentration and the fewer units you need per dose. The tool computes this for every week of the schedule and shows the syringe live.
Reconstitution and bacteriostatic water
Reconstituting means dissolving the freeze-dried powder in liquid. For research peptides you use sterile bacteriostatic water. Inject the water slowly along the glass wall of the vial, swirl gently until everything dissolves and never shake. Store the reconstituted vial refrigerated (2–8 °C) and away from light.
Frequently asked questions
What dose do you start retatrutide at?
In research, a low dose is often used at the start and increased every four weeks. Common starting values are around 2 mg per week, with a target dose of 8 to 12 mg. Set your own start, target and step values in the tool to see your schedule.
How many units of retatrutide do I draw?
That depends on your concentration. Example: a 20 mg vial dissolved in 2 ml of water gives 10 mg/ml. A 4 mg dose is then 0.4 ml = 40 units on a U-100 syringe. The tool calculates this per week automatically.
How much water do I use to dissolve retatrutide?
There's no fixed amount — more water makes low doses easier to measure, less water keeps higher doses within one syringe. 1 to 3 ml per vial is common. If the tool warns the dose doesn't fit the syringe, use less water.
How long does reconstituted retatrutide last?
Once reconstituted, most peptides last about 3–4 weeks refrigerated (2–8 °C), provided they're prepared with bacteriostatic water and kept away from light. Always check the label of the specific product.