Ordered Friday 3 PM, delivered Tuesday morning in Utrecht. Neatly packed and the COA simply arrived by email.
Sven K.
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5-Amino-1MQ
NNMT inhibitor, the small molecule behind the NAD+ research.
4.5 · 12 reviews≥ 99.4% HPLCLab-verifiedLongevity researchResearch only
Buy 5-Amino-1MQ, research-grade, ≥99% HPLC, shipped same day from the Netherlands. A small synthetic molecule that inhibits the enzyme NNMT, which is why it is studied in research on NAD+, fat metabolism and cellular energy. Not a peptide and not a supplement, strictly for laboratory research.
€ 34,95
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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small synthetic molecule that blocks the enzyme NNMT (nicotinamide N-methyltransferase). That enzyme is of interest in research because it plays a part in fat metabolism and in how cells maintain their NAD+ supply. This is exactly why 5-Amino-1MQ keeps turning up in studies on metabolism, fat oxidation and cellular energy. At GradePurity you buy it as a research-grade vial: ≥99% HPLC purity, shipped the same day from the Netherlands. It is strictly a research material for the lab, not a peptide, not a dietary supplement and not intended for human use.
What does 5-Amino-1MQ do?
5-Amino-1MQ is an inhibitor of the enzyme NNMT. In the fat cell, this enzyme is involved in how quickly fat is burned and how large fat cells grow; in research, NNMT stands out mainly because it is elevated in obesity. By dialling NNMT down, animal and cell studies look at whether the cell shifts more towards fat oxidation and whether NAD+ levels rise. It is assumed that this is where the interest in 5-Amino-1MQ comes from in research on metabolism and body composition. We make no health claims about it ourselves, at GradePurity it is purely a research material, not for use in humans.
How does 5-Amino-1MQ work?
The enzyme NNMT uses up two things the cell badly needs: a methyl group (from SAM, S-adenosylmethionine) and nicotinamide, the building block the cell makes NAD+ from. By blocking NNMT, 5-Amino-1MQ spares both in research: more nicotinamide is left to recycle into NAD+, and the SAM economy is less burdened. That higher NAD+ availability is also where the link to the sirtuins, the maintenance enzymes of the cell, comes from. Most of what we know about this comes from cell and animal studies.
Not a peptide, but a small molecule
This is the biggest misconception around 5-Amino-1MQ: it is often called a "peptide", but it is not one. It is a small synthetic molecule (a quinolinium derivative), small enough to cross the cell membrane on its own, unlike most research peptides. It only gets mentioned in the same breath as peptides because it is studied in the same metabolic and longevity context. For the lab, the difference mostly matters for how you dissolve and store it; the specifications are in the table at the bottom of this page.
5-Amino-1MQ and NAD+
The reason 5-Amino-1MQ gets so much attention in the longevity corner is its indirect route to NAD+. NAD+ is the coenzyme cells use to release energy, and its natural supply falls as we age. Because NNMT siphons off nicotinamide that would otherwise become NAD+, research looks at whether inhibiting NNMT helps keep NAD+ levels higher. That puts 5-Amino-1MQ in the same line of research as NAD+ itself, but approaching the problem from the other side. If you want to study the coenzyme itself, look at our NAD+ vial; 5-Amino-1MQ is the NNMT-inhibitor side of the same story.
Dosage and form: vial or capsule
On the market you will see 5-Amino-1MQ in two forms: as capsules (often 50 mg) and as a freeze-dried vial. We deliberately supply the research-grade vial, because it lets you set the concentration yourself in the lab and work with the pure molecule, capsules are finished consumer products with fillers. Research protocols for the vial usually describe dissolving the molecule and measuring out small daily amounts. We deliberately give no human dosing advice: 5-Amino-1MQ is a research material, and the right amount depends on the study design, not on a usage dose.
Side effects and safety
Because 5-Amino-1MQ is relatively new, almost all knowledge comes from cell and animal studies; large long-term human data are lacking. In those studies the molecule is known for a mild profile, partly because it acts selectively on a single enzyme (NNMT) rather than on the whole body. Exactly what happens with prolonged human use simply has not been investigated yet.
Purity and lab testing
With a small molecule like this, usable research stands or falls with the purity of your material. That is why we test every batch by HPLC for ≥99% purity and identity, and ship it freeze-dried so it arrives stable. So you know exactly what you are holding, the exact specifications (purity, molecular weight, CAS) are in the table at the bottom of this page.
Frequently asked questions
What our customers say.
Verified buyers across the Netherlands
★★★★★4.9 / 5Verified
BPC-157
Finally a supplier that just shows the HPLC + MS figures. Purity was exactly as promised.
Lotte v.d. B.
Verified purchase
Fast parcel out of the Netherlands. Emailed a question, got a reply within a few hours. Top service.
Paul M.
Verified purchase
Next business day in Rotterdam. Well and discreetly packed, will definitely order again.
Marco R.
Verified purchase
Ordered around 3 PM, delivered Wednesday morning. Unbranded envelope, my courier had no idea what was inside.
Niels J.
Verified purchase
Within 24 hours from NL stock. COA with MS identity confirmation — hard to find anywhere else.
Jonas W.
Verified purchase
Delivery spot-on, COA detailed. Would appreciate a more extensive FAQ per peptide on the site.
Eva R.
Verified purchase
Ordered Tuesday before 4 PM, at my door Wednesday in Breda. Payment went flawlessly.
Bram H.
Verified purchase
Genuinely from NL stock, so no customs hassle. Vial well freeze-dried, everything tightly packed.
Femke S.
Verified purchase
Purity on the HPLC comfortably above 99%. Delivery a day later than hoped, nothing else to fault.
Thijs M.
Verified purchase
Ordered Friday 3 PM, delivered Tuesday morning in Utrecht. Neatly packed and the COA simply arrived by email.
Sven K.
Verified purchase
Finally a supplier that just shows the HPLC + MS figures. Purity was exactly as promised.
Lotte v.d. B.
Verified purchase
Fast parcel out of the Netherlands. Emailed a question, got a reply within a few hours. Top service.
Paul M.
Verified purchase
Next business day in Rotterdam. Well and discreetly packed, will definitely order again.
Marco R.
Verified purchase
Ordered around 3 PM, delivered Wednesday morning. Unbranded envelope, my courier had no idea what was inside.
Niels J.
Verified purchase
Within 24 hours from NL stock. COA with MS identity confirmation — hard to find anywhere else.
Jonas W.
Verified purchase
Delivery spot-on, COA detailed. Would appreciate a more extensive FAQ per peptide on the site.
Eva R.
Verified purchase
Ordered Tuesday before 4 PM, at my door Wednesday in Breda. Payment went flawlessly.
Bram H.
Verified purchase
Genuinely from NL stock, so no customs hassle. Vial well freeze-dried, everything tightly packed.
Femke S.
Verified purchase
Purity on the HPLC comfortably above 99%. Delivery a day later than hoped, nothing else to fault.
Thijs M.
Verified purchase
The BPC + TB stack comes as two separate vials, each with its own COA. Not pre-mixed — exactly what I wanted.
Tom B.
Verified purchase
The COA was clear and readable. Delivered the next business day in The Hague. Helpful support by email.
Charlotte F.
Verified purchase
Arrived in a plain, neutral envelope. My neighbour who took it in literally had no clue what was inside. Privacy = 10.
Anouk d. V.
Verified purchase
Purity per COA 99.3%. Vial nicely freeze-dried, no yellow discolouration. Shipping from NL trouble-free.
Lukas K.
Verified purchase
Emailed a question on Saturday, Monday morning I got a reply from a real person. No cookie-cutter template. Real service.
Sara P.
Verified purchase
Shipped to Tilburg in one business day. Payment trouble-free. Identity neatly confirmed by MS on the COA.
Daniel S.
Verified purchase
Second order. The first was problem-free, so no reason to look elsewhere. COA again with HPLC + MS figures.
Iris K.
Verified purchase
Messaged a question about storage, got a clear answer. Nice that there is simply someone reachable.
Joris V.
Verified purchase
Completely neutral packaging, nothing visible on the outside. Delivered next day in Nijmegen. Exactly what I was after.
Sanne D.
Verified purchase
Shipped quickly from the Netherlands, and the COA confirmed the purity nicely. Third time ordering here without complaints.
Ruben T.
Verified purchase
The BPC + TB stack comes as two separate vials, each with its own COA. Not pre-mixed — exactly what I wanted.
Tom B.
Verified purchase
The COA was clear and readable. Delivered the next business day in The Hague. Helpful support by email.
Charlotte F.
Verified purchase
Arrived in a plain, neutral envelope. My neighbour who took it in literally had no clue what was inside. Privacy = 10.
Anouk d. V.
Verified purchase
Purity per COA 99.3%. Vial nicely freeze-dried, no yellow discolouration. Shipping from NL trouble-free.
Lukas K.
Verified purchase
Emailed a question on Saturday, Monday morning I got a reply from a real person. No cookie-cutter template. Real service.
Sara P.
Verified purchase
Shipped to Tilburg in one business day. Payment trouble-free. Identity neatly confirmed by MS on the COA.
Daniel S.
Verified purchase
Second order. The first was problem-free, so no reason to look elsewhere. COA again with HPLC + MS figures.
Iris K.
Verified purchase
Messaged a question about storage, got a clear answer. Nice that there is simply someone reachable.
Joris V.
Verified purchase
Completely neutral packaging, nothing visible on the outside. Delivered next day in Nijmegen. Exactly what I was after.
Sanne D.
Verified purchase
Shipped quickly from the Netherlands, and the COA confirmed the purity nicely. Third time ordering here without complaints.
Ruben T.
Verified purchase
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